Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods Fourth Edition edited by Robert L. Bronaugh and Howard I. Maibach

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Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods

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Features

With contributions from 90 leading experts at the forefront of the discipline, this reference

  • contains recent studies on the role of the skin as a key portal of entry for chemicals into the body
  • serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel
  • details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption
  • considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery
  • discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
  •  

    Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Fourth Edition supplies new chapters on topics currently impacting the field including:

    • cutaneous metabolism
    • skin contamination
    • exposure to protein allergens
    • in vitro absorption methodology
    • the percutaneous absorption of chemical mixtures
    • the penetration of chemicals through the hair follicles
    • dermal drug delivery
    • mechanisms of absorption
    • nanoparticles and dermal absorption
    • the absorption of drugs and cosmetic ingredients
    • nail penetration
    • and other current research

    Contents of the 3rd edition

    MECHANISMS OF ABSORPTION

     

    • Mathematical Models in Percutaneous Absorption
    • Cutaneous Metabolism During In Vitro Percutaneous Absorption
    • Cutaneous Metabolism of Xenobiotics
    • Occlusion Does Not Uniformly Enhance Penetration In Vivo
    • Regional Variation in Percutaneous Absorption
    • In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss
    • Skin Contamination and Absorption of Chemicals from Water and Soil
    • Characterization of Molecular Transport Across Human Stratum Corneum In Vivo
    • Relationship Between H-Bonding of Penetrants to Stratum Corneum Lipids and Diffusion
    • In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/ Vehicle Partitioning

    METHODOLOGY

     

    • In Vivo Methods for Percutaneous Absorption Measurements
    • Determination of Percutaneous Absorption by In Vitro Techniques
    • Will Cutaneous Levels of Absorbed Material Be Systemically Absorbed?
    • Dermal Decontamination and Percutaneous Absorption
    • Partitioning of Chemicals from Water into Powdered Human Stratum Corneum (Callus)�A Model Study
    • In Vitro Percutaneous Absorption of Model Compounds Glyphosate and Malathion from Cotton Fabric into and Through Human Skin
    • Vaginal Absorption of Prostaglandin E1 in Rhesus Monkey
    • Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Efffects of Heat Separation and Freezing
    • Interrelationships in the Dose Response of Percutaneous Absorption
    • Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques
    • Drug Concentration in the Skin
    • Stripping Method for Measuring Percutaneous Absorption In Vivo
    • Tape-Stripping Technique
    • Interference with Stratum Corneum Lipid Biogenesis: An Approach to Enhance Transdermal Drug Delivery
    • Percutaneous Drug Delivery to the Hair Follicle
    • Relative Contributions of Human Skin Layers to Partitioning of Chemicals with Varying Lipophilicity
    • Effect of Single Versus Multiple Dosing in Percutaneous Absorption
    • Measurement of Short-Term Dermal Uptake In Vitro Using Accelerator Mass Spectrometry
    • New Developments in the Methodology Available for the Assessment of Topical Corticosteroid-Induced Skin Blanching
    • Raman Spectroscopy
    • Stratum Corneum and Barrier Performance: A Model Lamellar Structural Approach
    • Role of In Vitro Release Measurement in Semisolid Dosage Forms
    • Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, and p-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Humans In Vivo
    • Transepidermal Water Loss Measurements for Assessing Skin Barrier Functions During In Vitro Percutaneous Absorption Studies

    DRUG AND COSMETIC ABSORPTION

     

    • Percutaneous Penetration as a Method of Delivery to Skin and Underlying Tissues
    • Phonophoresis
    • Facilitated Transdermal Delivery by Iontophoresis
    • Percutaneous Penetration as It Relates to the Safety Evaluation of Cosmetic Ingredients
    • Percutaneous Absorption of Fragrances
    • Hair Dye Absorption
    • Percutaneous Absorption of Alpha-Hydroxy Acids in Human Skin
    • Optimizing Patch Test Delivery: A Model
    • Permeation of N-Nitrosamines Through Human Skin
    • Nail Penetration: Focus on Topical Delivery of Antifungal Drugs for Onychomycosis Treatment
    • Topical Dermatological Vehicles: A Holistic Approach
    • Human In Vivo and In Vitro Hydroquinone Topical Bioavailability, Metabolism, and Disposition
    • Human Skin In Vitro Percutaneous Absorption of Gaseous Ethylene Oxide from Fabric
    • In Vivo Percutaneous Absorption of Acetochlor in Rhesus Monkey: Dose Response and Exposure Risk Assessment
    • The Development of Skin Barrier Function in the Neonate
    • Percutaneous Absorption of Sunscreens
    • Microemulsions
    • Bioavailability of [14C] Hydroquinone in F344 Rat and Rhesus Monkey
    • Dermatopharmacokinetics of Topical BCX-34 Cream in Human Skin
    • In Vitro Cutaneous Disposition of a Topical Diclofenac Lotion in Human Skin: Effect of a Multidose Regimen
    • An Innovative Method to Determine Percutaneous Absorption: Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling
    • Role of Calcium Ions in Relation to Skin Barrier Function

    Index

     

     

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