During the past few years, significant scientific evidence has accumulated to show that nutrition-based strategies are capable of exerting beneficial effects on the skin. This exceptional reference • describes the scientific basis for nutrition-based strategies, • summarizes the evidence that functional food for skin really works, and • addresses key practical issues regarding the use of nutrition-based strategies in clinical and cosmetic dermatology. It is anticipated that this helpful guide, written by acclaimed international experts, will become the gold standard on the role of nutrition in ensuring healthy skin. It will be of interest to a wide audience, including dermatologists, food industry staff, patients, and consumers.

1 Cutaneous Changes in Nutritional Diseases . . . . . . . . . . . . . . . . . . . . . . 3
Matthias Schmuth and Peter O. Fritsch
2 Skin Aging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Jean Krutmann
3 Non-melanoma Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Mark Berneburg
4 Skin Barrier Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Peter M. Elias and Joan S. Wakefield

Part II: Functional Food for Skin Works: Intervention
Studies in Humans and Animal Models

5 Botanical Antioxidants for Skin Protection: An Overview . . . . . . . . . . 51
Farrukh Afaq and Hasan Mukhtar
6 Systemic Photoprotection by Carotenoids . . . . . . . . . . . . . . . . . . . . . . . . 65
Wilhelm Stahl
7 Systemic and Topical Use of Green
Tea Polyphenols for Healthy Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Aton M. Holzer, Nabiha Yusuf, Brandon Tisdale,
Santosh K. Katiyar, and Craig A. Elmets
8 Flavonoid-Rich Nutrients for the Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Wilhelm Stahl
9 Omega-3 Fatty Acids and Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Suzanne Margaret Pilkington and Lesley Elizabeth Rhodes
10 Potential Benefits of Soy for Skin, Hair, and Nails . . . . . . . . . . . . . . . . . 109
Robert M. Blair and Aaron Tabor
11 Photoprotection by Nicotinamide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Diona L. Damian and Gary M. Halliday
12 Probiotics and Regulation of Immune Responses . . . . . . . . . . . . . . . . . . 129
Josette Péguet-Navarro
13 Prebiotic Cosmetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Rainer Simmering and Roland Breves
14 Micronutrients for Hair and Nails . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
E. Haneke and Robert Baran

15 Legal Aspects: How Do Food Supplements Differ
from Drugs, Medical Devices, and Cosmetic Products? . . . . . . . . . . . . . 167
Helena Karajiannis and Catherine Fish
16 How to Prove Safety and Efficacy
in Nutrition-Based intervention Studies for Human Skin . . . . . . . . . . . 181
Christiane Montastier, Sophie Mac-Mary, Jean Krutmann,
and Philippe Humbert
17 Beauty from Inside: Nutrition-Based Strategies
in Cosmetic Dermatology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
Philippe Humbert, D. Binda, S. Robin, and Jean Krutmann
Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203