Transport Processes in Pharmaceutical Systems By Gordon L. Amidon, Ping I. Lee, Elizabeth M. Topp

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Transport Processes in Pharmaceutical Systems

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Summary

This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity.
Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems.
Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems

 

  • discusses the crucial relationship between the transport process and thermodynamic factors 
  • analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces 
  • covers prodrug design for improving membrane transport 
  • addresses the effects of external stimuli in altering some natural and synthetic polymer matrices 
  • examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability 
  • presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions 
  • and more!
    Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

    TABLE OF CONTENTS :

    Introduction to Transport Processes

  • Principles of Mass Transfer
    Elizabeth M. Topp
    Analytical Solutions to Mass Transfer
    Lawrence X. Yu and Gordon L. Amidon
    Pharmacokinetics: Model Structure and Transport Systems
    James M. Gallo
    Experimental Methods to Evaluate Diffusion Coefficients and Investigate Transport Processes of Pharmaceutical Interest
    John W. Mauger
    Dissolution of Pharmaceuticals in Simple and Complex Systems
    Daniel P. McNamara, Michael L. Vieira, and John R. Crison

    Biological Transport Processes

    Biological Transport Phenomena in the Gastrointestinal Tract: Cellular Mechanisms
    David Fleisher
    Improving Oral Drug Transport via Prodrugs
    Mandana Asgharnejad
    Quantitative Approaches to Delineate Passive Transport Mechanisms in Cell Culture Monolayers
    Norman F. H. Ho, Thomas J. Raub, Phillip S. Burton, Craig L. Barsuhn, Anthony Adson, Kenneth L. Audus, and Ronald T. Borchardt
    Barriers to Drug Transport in Ocular Epithelia
    Uday B. Kompella and Vincent H. L. Lee
    Predicting Oral Drug Absorption in Humans
    Lawrence Yu, Larry Gatlin, and Gordon L. Amidon

    Transport Processes in Polymer Systems

    Controlled Release Osmotic Drug Delivery Systems for Oral Applications
    John R. Cardinal
    Transport in Polymer Systems
    Jim H. Kou
    Synthesis and Properties of Hydrogels Used for Drug Delivery
    Stevin H. Gehrke
    Stimuli-Modulated Delivery Systems
    Sung Wan Kim and You Han Bae
    Properties of Solids that Affect Transport
    Manesh J. Nerurkar, Sarma Duddu, David J. W. Grant, and J. Howard Rytting

    Heat and Mass Transport

    Heat and Mass Transfer in Low Pressure Gases: Applications to Freeze Drying
    Michael J. Pikal
    Heat and Mass Transport: Hygroscopicity
    James Wright
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    Transport Processes in Pharmaceutical Systems

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