Traditional Herbal Medicine Research Methods Identification, Analysis, Bioassay, and Pharmaceutical and Clinical Studies

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Traditional Herbal Medicine Research Methods
Identification, Analysis, Bioassay, and Pharmaceutical and Clinical Studies
edited by Willow J. H. Liu
Traditional Herbal Medicine Research Methods: Identification, Analysis, Bioassay, and Pharmaceutical and Clinical Studies covers:

the methodology for collection and identification of herbal materials
extraction and isolation of compounds from herbs
in vitro bioassay
in vivo animal test
toxicology
clinical trials of herbal research
Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book covers the systematic study and analysis of herbal medicines in general – including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.

Contents

1. Introduction to Traditional Herbal Medicines and Their Study


Definition and Trends of Traditional Herbal Medicines
Research and Development of Herbal Medicines
Common Mistakes Seen in Research on Traditional Herbal Medicines
Research on Traditional Herbs Should Refer to Theories and Clinical Application of Traditional Medicine
Brief Introduction of Different Systems of Traditional Medicine
Regulation of Herbal Medicines and Their Products
Achievements and Challenges of Research on Chinese Herbal Medicines
2. Collection and Identification of Raw Herbal Materials


Collection of Herbal Materials
Methods for Species Identification of Herbal Materials
3. Extraction and Isolation of Compounds from Herbal Medicines


Compounds in Plants and Their Structures and Properties
Methods for Extraction of Herbal Medicines
Methods for Isolation of Compounds from Herbal Extracts
An Example of Extraction and Compound Isolation from Herbal Medicine
4. Identification and Structure Elucidation of Compounds from Herbal Medicines


Structural Characteristics and Chemical Identification of Compounds in Herbal Medicines
Brief Introduction of UV, IR, NMR, MS, and other Spectra
Identification of Compounds by HPLC and TLC
Identification of Compounds By Spectra
Structure Elucidation of Unknown Compounds by Hyphenated Technique
5. Bioassays for Screening and Functional Elucidation of Herbal Medicines


History of Screening Compounds from Natural Products for Drug Development
Brief Introduction of Enzymes, Receptors, Cells, and Gene Expression
Selection of Bioassay
Evaluation of Bioassay Results of Herbal Samples
Enzyme Binding Assay
Receptor Binding Assay
Gene Expression Assays
New Technologies and other Bioassays for Screening and Mechanism Study
Keys to Functional Mechanism Study of Herbal Medicines
Example 1. Screening and Evaluation of Estrogenic Activity of Herbal Medicines
Example 2. Functional Elucidation of Black Cohosh for Menopause Symptoms
6. Functional Evaluation of Herbal Medicines by Animal Experiments


Purposes and Significance of Pharmacological Research for Herbal Medicines
Characteristics of Pharmacological Research of Herbal Medicines
Design of Pharmacological Study on Herbal Medicines
Examples of In Vivo Experiments for Herbal Extracts
7. Safety Pharmacology and Toxicity Study of Herbal Medicines


Safety Pharmacology
Acute Toxicity Study
Chronic Toxicity Study
Special Toxicity Study
Examples of In Vivo Toxicological Experiments for Compounds or Extracts from Herbal Medicines
8. Clinical Study of Traditional Herbal Medicine


Introduction to Clinical Trials and Challenge of Clinical Trials on Herbal Medicines
Essential Elements and Principles of Clinical Trial Design
Design of Clinical Trials
Examples of Clinical Trials
9. Standardization and Quality Control of Herbal Extracts and Products


Introduction of QA, QC, and GMP
Standardizations and SOP of Herbal Extracts
Equipment for Quality Control of Herbal Extracts and Products
Qualitative Analysis of Herbal Extracts and Products
Quantitative Analysis of Herbal Extracts and Products
10. Understanding Traditional Chinese Medicine and Chinese Herbs


Understanding TCM Theories with Modern Medical Terminology
Chemicals are Fundamental Substances Refl ecting Functions of Chinese Herbs
Brief Introduction to the Properties of Chinese Herbs
Modern Pharmacology of Chinese Herbal Medicine
Chinese Herbal Formulas
Index



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