The Biochemistry of Drug Metabolism: Volume 2: Conjugations, Consequences of Metabolism, Influencing Factors By Bernard Testa, Stefanie D. Kramer
The Biochemistry of Drug Metabolism: Volume 2: Conjugations, Consequences of Metabolism, Influencing Factors
The next part examines the consequences of drug and xenobiotic metabolism in a pharmacological and toxicological perspective, with due attention paid to full activation, as is found with prodrugs, and to the worrying case of xenobiotic toxification.
Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species. Focusing on humans, the most relevant polymorphic drug-metabolizing enzymes are discussed, concentrating on ethnic differences and on the consequences for the pharmacokinetic behavior of affected drugs, while also introducing sex-dependent metabolic reactions.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction via nuclear receptors and the different mechanisms of enzyme inhibition are explained. With these basics in mind, various influencing factors are discussed, including physiological and pathological conditions, as well as drugs, nutrients and environmental agents with a special focus on drug-drug interactions.
With a foreword by Prof Leslie Z. Benet -- the best and best-known biopharmaceutical scientist worldwide.
"These two volumes provide a comprehensive scientific basis for the study of the biochemistry of drug metabolism. The text is practically organized with extensive literature and information figures. As well as providing fundamental knowledge towards understanding the principles of drug metabolism, to those new to the subject, both volumes represent an invaluable reference for researchers in the field of biochemistry, pharmacology and new drug development". (Anticancer Research, 1 August 2010)
Related Products
-
A Practical Guide to Assay Devel...
13,464.00
16,830.00 -
A Textbook of Modern Toxicology,...
8,942.00
10,520.00 -
Active Pharmaceutical Ingredient...
3,200.00
3,495.00 -
Active Pharmaceutical Ingredient...
14,850.00
17,500.00 -
Advanced Distillation Technologi...
13,500.00
15,000.00 -
Aesthetics Exposed: Mastering Sk...
17,000.00
- Architecture & Construction Management Books
- Biochemistry, Bioengineering and Biotechnology Books
- Books on Analytical Techniques, GC MS, LC, TLC, HPLC, NMR Spectroscopy
- Books on Water and Wastewater Treatment, Analysis Water Treatment Plants
- Chemical Technology, Organic Chemistry, Chemical Synthesis and Chemical Analysis Books
- Cosmetics Science, Cosmetics Formulations, Manufacture and their Analysis Books
- Drugs and Pharma Science Books
- Essential Oils, their Analysis, Natural Products Extraction, Distillation , Isolates Related Books
- Flavor Science, Flavor Analysis, Flavor Creation, Food Flavors Books
- Food Science and Technology, Baking , Food Ingredients , Food Quality , Food Regulations
- Formulations of Perfumes for Agarbatti, Air Freshners, Soaps & Detergents, Fabric Softeners , French style Perfumes, Attars , OUD, Fine Fragrances
- Fragrances, Scents, Attars , Perfumery and Aroma Chemicals Books
- Herbal, Ayurvedic, Medicinal Plants and Aromatic Plants Books
- Law Books
- Major Reference Works (MRWS) Sets - MultiVolume Sets
- Medical Books
- Medical Journals Wolters Kluwer | Medknow India
- NEW ARRIVALS
- Perfumer's Resources
- Special Indian Reprint !
- VILLAGE COTTAGE : Scents and Soaps - Luxury Bathing Soaps