Textbook of Clinical Trials Second edition

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Textbook of Clinical Trials
Second edition

edited by
David Machin


Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume.

The book's main concept is to describe the impact of clinical trials on the practice of medicine. It separates the information by therapeutic area because the impact of clinical trials, the problems encountered, and the numbers of trials in existence vary tremendously from specialty to specialty.

The sections provide a background to the disease area and general clinical trial methodology before concentrating on particular problems experienced in that area. Specific examples are used throughout to address these issues.


Highlights the various ways clinical trials have influenced the practice of medicine in many therapeutic areas
Describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields
Additional therapeutic areas are included in this Second Edition to fill gaps in the First Edition as the number and complexity of trials increases in this rapidly developing area
Newly covered or updated in the Second Edition: general surgery, plastic surgery, aesthetic surgery, palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal, thyroid and urological cancers, as well as a chapter on the Cochrane network
Textbook of Clinical Trials, Second Edition is an invaluable resource for pharmaceutical companies.



The Development of Clinical Trials
General Statistical Issues
The Cochrane Collaboration

Breast Cancer
Childhood Cancer
Gastrointestinal Cancers
Respiratory Cancers
Adrenal Cortical Carcinoma
Thyroid Cancer
Urologic Cancers
Haematologic Cancers: Challenges in Developing New Therapeutic Approaches

Acute Stroke
Cardiovascular Disease
Dentistry and Oral Health Care

Dentistry and Oral Health Care

Infectious Diseases

HIV Infection
Infectious Diseases


Anxiety Disorders
Cognitive Behaviour Therapy
Psychotherapy for Depression
Reproductive Health

Gynaecology and Infertility
Early Pregnancy Termination
Maternal and Perinatal Health

Respiratory Medicine
Surgery and Anaesthesia

Anaesthesia and Pain
General Surgery
Plastic Surgery – Reconstructive Surgery
Plastic Surgery – Aesthetic Surgery

Renal Transplantation
Other Processes

Wound Healing
Palliative Care
Complementary Medicine
Cluster Randomized Trials in Health Care Research
Special Populations

Clinical Trials in Paediatrics
Clinical Trials Involving Older People
Clinical Trials in Rare Diseases

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