Scent and Chemistry The Molecular World of Odors by Günther Ohloff

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Scent and Chemistry
The Molecular World of Odors
by Günther Ohloff


Scent and Chemistry: The Molecular World of Odors presents a vivid and up-to-date picture of the chemistry of odorants and the research in odor perception.

Coverage includes:

  • the molecular basis of olfaction
  • olfactory characterization of perfumery materials
  • structure-odor relationships
  • chemical synthesis of odorants
  • chemistry of essential oils and odorants from the animal kingdom
  • notes in perfumery for each essential oil


1. Historical Aspects


  • Scents of Time
  • Chemical Discoveries and Modern Perfumery

2. The Chemical Senses


  • Anatomy, Physiology, and Biochemistry of Olfactory Receptors
  • Historical Aspects
  • Description and Classification of Odor Impressions
  • Historical AspectsQuantitative Odor Perception

3. Structure-Odor Relationships


  • Physicochemical Properties of Odorants and the Concept of Osmophoric Groups
  • Structure-Odor Correlations
  • Molecular Shape and Odor – The Early Theories
  • The Concept of Profile and Bulky Groups
  • Unsaturated Compounds
  • Diastereoisomers
  • Steroid-Type Odorants
  • Odor Rules
  • Bifunctional Units: Mugent and Caramel Odorants
  • QSAR: Homology vs. Olfactophore Models
  • Enantioselectivity of the Odor Sensation

4. Odorants from Natural Sources


  • Important Terpene Building Blocks
  • Odorants from α- and β-Pinene
  • Synthetic Odorants from Cyclic Monoterpenes
  • Acyclic Odorants of the Monoterpene Series
  • Odorants from 3,7-Dimethylocta-1,6-diene
  • Odorants by Functionalization of Myrcene
  • Odorants from (-)-Caryophyllene and (+)-Longifolene
  • Odorants from α=Cedrene and Thujopsene

5. Odorants from Petrochemical Sources


  • Isoprene as Starting Material for the Synthesis of Odorants
  • Isobutene and 3-Methylbut-1-en-2-ol as Starting Materials
  • Terpenoids from Isobutene
  • (-)-Menthol

6. Ionones, Damascones, and Iso E Super


  • Violet and Orris Odorants
  • Rose Ketones
  • Isocyclemones: Ionone-Type materials in Perfumery

7. Essential Oils


  • Citrus Oils
  • Petigrain Oil
  • Neroli Oil/Orange Blossoms
  • Lavender Oil
  • Clary Sage Oil
  • Patchouli Oil
  • Jasmine Absolute
  • Rose Oil
  • Geranium Oil
  • Violet Oil
  • Orris
  • Osmanthus Oil
  • Vetiver Oil
  • Cedarwood Oil
  • Sandalwood Oil
  • Galbanum
  • Labdanum
  • Oakmoss
  • Incense and Myrrh
  • Black and Pink Pepper

8. Odorants of Animal Origin


  • Musk and Civet
  • Industrial Synthesis of Macrocyclic Odorants
  • Non-Natural Musks
  • Ambergris
  • Castoreum



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