Receptor - Based Drug Design Editor(s):Paul Leff

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Receptor - Based Drug Design


Table of Contents

Introduction, James Black 

Principles and Measurement of Drug-Receptor Interactions 

The Characterization and Classification of Receptors, Patrick P. A. Humphrey
Functional Methods for Quantifying Agonists and Antagonists, Iain G. Dougall
Quantification of Receptor Interactions Using Binding Methods, Sebastian Lazareno
Drug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, José L. Boyer, and Robert W. Dougherty
The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles Kennedy

Receptor-Based Drugs in Medicine 

Selective Adrenergic and Glucocorticoid Treatments for Asthma, David Jack
Serotonin 5-HT1B/D Receptor Agonists, Graeme R. Martin
Histamine H2-Receptor Antagonists, Michael E. Parsons
Angiotensin Antagonists, Mark J. Robertson

Experimental and Emerging Drugs 

-Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr.
P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. Boucher
Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. Eglen
NMDA Receptor Antagonists, John A. Kemp and James N. C. Kew

New Trends in Drug Design 

Computational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma Kuipers
Recombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. Fernandes
Inverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier

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