Drug-Drug Interactions in Pharmaceutical Development edited by Albert P. Li

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Drug-Drug Interactions in Pharmaceutical Development
edited by Albert P. Li
Drug-Drug Interactions in Pharmaceutical Development covers the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions.

The book focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market.

Drug-Drug Interactions in Pharmaceutical Development also covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Contents


In Vitro evaluation of metabolic drug-drug interactions: concepts and practice
In Vitro approaches to anticipating clinical drug interactions
Inhibition of drug-metabolizing enzymes and drug-drug interactions in drug discovery and development
Mechanism-based CYP inhibition: enzyme kinetics, assays, and prediction of human drug-drug interactions
Genomic approaches to drug-drug interactions
Transporters and drug interactions
Transporter-mediated drug interactions: molecular mechanisms and clinical implications
Recent case studies of clinically significant drug-drug interactions and the limits of In Vitro prediction methodology
U.S. regulatory perspective: drug-drug interactions
Herbal drug interactions�a Canadian perspective
Index


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