Biotechnology of Antibiotics Second Edition edited by William R. Strohl

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Biotechnology of Antibiotics


Second Edition
edited by William R. Strohl

840 pages 

 

 

This incomparable Second Edition of a highly regarded reference has been entirely rewritten and enlarged to reflect the explosion of information and technologies that have emerged since the publication of the previous edition.

Strikes the perfect balance between proven traditional approaches and modern methods that promise to yield new products and processes!

Specifically addressing microbially derived commercially important bioactive products that are currently or soon-to-be available, Biotechnology of Antibiotics, Second Edition:

  • analyzes the use of recombinant enzymes to produce biologically active molecules, including a cholesterol-lowering agent, an anti-HIV drug for the treatment of AIDS, and b-lactam antibiotics
  • gives insight into the biochemistry, molecular biology, and production of antibiotics used as therapeutic agents
  • focuses on state-of-the-art techniques for the development of new antibiotics using novel approaches and strategies
  • highlights recent advances in the genetic manipulation of antibiotic biosynthesis genes to create structures from gene combinations for new biological activities
  • describes in detail the development and current status of newly created antibiotics and pharmacologically active natural products
  • and much more!

Written by authorities from both industry and academia and containing nearly 4000 bibliographic citations, Biotechnology of Antibiotics, Second Edition is an outstanding resource for pharmaceutical scientists, medicinal chemists and biochemists, molecular biologists and industrial microbiologists, chemical engineers, fermentation bioengineers, bioprocess technologists, and upper-level undergraduate and graduate students in these disciplines.

Contents

  • Introduction and Approaches for Improvement in Antibiotic Production
    • Industrial Antibiotics: Today and the Future
    • Molecular Genetic Approaches to Yield Improvement in Actinomycetes
    • Butyrolactone Autoregulators, Inducers of Virginiamycin in Streptomyces virginiae: Their Structures, Biosynthesis, Receptor Protein and Induction of Virginiamycin Biosynthesis

     

  • Aminoglycosides
    • Molecular Biology, Biochemistry, and Fermentation of Aminoglycoside Antibiotics
    • Fermentation, Biosynthesis, and Molecular Genetics of Lincomycin

     

  • Template-Biosynthesized Peptide and b-Lactam Antibiotics
    • Structure, Function, and Regulation of Genes Encoding Multidomain Peptide Synthetases
    • Enzymology of Peptide Synthetases
    • Comparative Genetics and Molecular Biology of b-Lactam Biosynthesis
    • Biosynthesis of Cyclosporins
    • Echinocandin Anti-Fungal Agents
    • Biochemistry and Genetics of Actinomycin Production
    • Vancomycin and other Glycopeptides
    • Thiopeptide Antibiotics
    • Lipopeptide Antibiotics Produced by Streptomyces reseosporus and Streptomyces fradiae

     

  • Ribosomally Synthesized Peptide Antibiotics
    • Nisin and Related Protein Antibiotics
    • Cationic Peptides

     

  • Polyketide Antibiotics Produced by Type-I Multifunctional Enzymes
    • Rapamycin, FK506, and Ascomycin-Related Compounds
    • Rifamycins
    • Polyene Antibiotics

     

  • Polyketide Antibiotics Produced by Type-II Polyketide Synthase Systems
    • Anthracyclines
    • Molecular Biology, Biochemistry, and Fermentation of Tetracycline Formation
    • Antibiotics from Genetically Engineered Microorganisms

     

  • Peptydil Nucleoside Antibiotics
    • Blasticidin S and Related Peptidyl Nucleoside Antibiotics

     

  • Recombinant Bioconversions of Bioactive Molecules
    • New Processes for Production of 7-ACA from Cephalosporin
    • Chemoenzymaic Production of the Antiviral Agent Epivir
    • Biochemical and Fermentation Technological Approaches to Production of Pravistatin, a HMG-CoA Reductase Inhibitor
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