A Dermatological View: From Physiology to Therapy by Howard I. Maibach, MD

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A Dermatological View: From Physiology to Therapy


Author: Howard I. Maibach, MD


A fully revised publication covering skin physiology, pharmacology and toxicology with cosmetic chemistry.


Format Details

  • Softcover
  • 448 Pages
  • Published 2011



Cosmetic dermatologists want to understand the physiology of skin—notably skin conditions they consider problematic and in need of treatment—whereas product developers would like to create a cosmetic product that treats this problematic skin in order to change its appearance. They are therefore all starting with the same problem in order to get effective, though respectively different, treatments.

A Dermatological View: From Physiology to Therapy is designed to satisfy both sides of the problematic skin equation. Written in partnership with numerous colleagues, Dr. Howard I. Maibach’s aim is ever toward medical advancement and sustained product development in his areas of primary clinical specialty and research-based interest, including dermatopharmacology, allergic contact dermatitis, and dermatotoxicology and pathology. The information in A Dermatological View is purposed to both illuminate and to instruct. Topics include:

  • Ethnic variation in skin properties
  • Physiological and methodological aspects of normal and damaged skin types
  • Enhanced skin penetration, including occlusive effects and active delivery systems
  • Skin sensitivity and allergic contact dermatitis
  • Anti-aging, -itch and –inflammation
  • And more!




  • Introduction by Johann W. Wiechers, PhD
  • Foreword
    • Section One: Normal Skin—Physiological and Methodological Aspects
      • 1: Ethnic Variation in Skin Properties: Quo Vadis? Part I
      • 2: Ethnic Variation in Skin Properties: Quo Vadis? Part II
      • 3: Variations in Pigmentation and Ultrastructural Skin Differences Among Ethnic Groups
      • 4: Advances in Stratum Corneum Biology and Understanding of Dry Skin
      • 5: Bioengineering Analysis of Water Hydration
      • 6: Skin Friction Coefficient Values
      • 7: Ceramides in Healthy and Diseased Skin
      • 8: Hormesis and Cosmetic Dermatology
      • 9: Tandem Irritants with Synergistic, Additive or Quenching Effects on the Skin
    • Section Two: Damaged Skin—Physiological and Methodological Aspect
    • — 2.1 Mechanical Damage
      • 10: Ceramides in Skin Stress: Ultraviolet, Tape Stripping and Crowding
      • 11: Effects of Occlusion: Wound Healing
      • 12: Evaluating Water Permeability and Occlusion in Wound Dressings and Topical Cosmetics
      • 13: Cosmetic Utilization of Micro Wound Healing Models
    • — 2.2 Chemical Damage
    • 2.2.1 Enhanced Skin Penetration
      • 14: Squanometry: An Early Predictor of Changes in the Skin Barrier
      • 15: Effects of Occlusion: Percutaneous Absorption
      • 16: In vitro Model for Decontamination of Human Skin
      • 17: Mechanisms of Tape Stripping and Protein Quantification
      • 18: Tape Stripping Method in Humans: Comparison of Evaporimetric Methods
      • 19: Correlating Transepidermal Water Loss and Percutaneous Absorption: An Overview
      • 20: Predicting the Percutaneous Penetration of Cosmetic Ingredients
      • 21: Clinical Relevance of Topical Active Delivery Systems in Cosmetics
    • 2.2.2 Sensitive Skin
      • 22: Three Decades of Patch Testing: Trends in a North American Populace
      • 23: Sensitive Skin Syndrome: Sensory Response and Classification
      • 24: Sensitive Skin Syndrome: Methodological Approaches
      • 25: Sensitive Skin Syndrome: Relationships Among Factors
    • 2.2.3 Allergic and Irritant Contact Dermatitis
      • 26: Gender and Dermatitis
      • 27: The Hardening Phenomenon in Irritant Contact Dermatitis: Cosmetic Implications
      • 28: Effects of Occlusion: Irritant and Allergic Contact Dermatitis
      • 29: Evaluating ACD Frequency After Reducing Exposure to Sensitizers
      • 30: Defining Clinically Relevant Fragrance Allergens: The Challenge (Part I)
      • 31: Defining Clinically Relevant Fragrance Allergens: The Challenge (Part II)
      • 32: Allergic Contact Dermatitis to Linalool
    • — 2.3 UV-damaged Skin
      • 33: Cutaneous Blood Flow in Aging Skin
      • 34: Cutaneous Biochemistry in Aging Skin
      • 35: Thickness of Aging Skin
    • Section Three: Cosmetic Therapies for Troubled Skin
    • — 3.1 Acnetic Skin
      • 36: Keratolytic Treatments for Acne: A Review
    • — 3.2 Anti-aging, -itch, inflammation, and Antioxidants
      • 37: Therapeutic Peptides in Aged Skin
      • 38: Evaluating Antipruritics
      • 39: Effect of Seawater Salts on Inflammatory Skin Disease
      • 40: Chemoprevention of Skin Cancer: Role of Antioxidants
      • 41: Antioxidant Inhibits UV Erythema In vivo in Humans
      • 42: Using Photochemiluminescence to Quantify the Antioxidative Capacity of Topicals
      • 43: A Rapid and Sensitive In vitro Method to Ascertain Antioxidative Capacity
    • — 3.3 Skin Moisturizers
      • 44: Advances in Dry Stratum Corneum Biology and Moisturization
      • 45: Moisturizer Efficacy: Evidence on Preventing and Treating Irritant Dermatitis
    • — 3.4 UV Protection
      • 46: Enhancing Sunscreen Efficacy for Realistic Application
    • — 3.5 Woundhealing
      • 47: Occlusion as an Active Agent
    • — 3.6 Translating Skin Physiology into Cosmetic Products
      • 48: Personal Care Products for Men
  • Index


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