Aging Skin: Current and Future Therapeutic Strategy By Linda D. Rhein, PhD and Joachim W. Fluhr, MD

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Aging Skin: Current and Future Therapeutic Strategy

Authors: Linda D. Rhein, PhD and Joachim W. Fluhr, MD



Format Details

  • Hardcover
  • 548 Pages
  • Published 2010


An “ageless” topic, strategies for combating skin aging is among the most advanced and advancing categories of personal care product development. Rhein and Fluhr’s Aging Skin is your ticket to this high-growth market.


Aging Skin presents leading-edge strategies to treat problems of aging skin. Current concepts are presented, along with fundamental research detailing the biochemical mechanisms underlying photodamage–the hallmark of aging skin. Based on the premise that aging and senescence occur due to a deterioration of cutaneous repair systems, topics covered include:

  • Novel approaches using growth factors that regulate fibrosis to facilitate "cutaneous wound repair" while preventing "solar scar"
  • Role of matrix metalloproteinases in the repair of photodamage
  • Role of angiogenesis and lymphangiogenesis in response to photodamage and strategies to regulate these processes
  • DNA repair and oxidative stress-resistant systems that aid in combating aging skin
  • Hormonal influences on skin aging, benefit of hormone replacement therapy and role of nutrition
  • Nonenzymatic glycation of matrix proteins due to oxidative stress-altering functionality and strategies to block such untoward reactions
  • Success of current treatments–retinoic acid, dermabrasion, Botox, peels and fillers
  • Design of the "optimal sunscreen" for prevention of photodamage
  • New skin-whitening strategies to reduce age spots by influencing melanogenesis

  • Introduction
  • Section 1: Leading Edge Concepts of Skin Aging
    • Mechanisms and Pathophysiology of photoaging and Chronological Skin Aging
    • Matrix Metalloproteinases, Fibrosis, and Regulation by Transforming Growth Factor Beta: a New Frontier in Wrinkle Repair
    • Aging and Epithelial Skin Cancer
    • The Role of Angiogenesis and Lymphangiogenesis in UVB-Induced Skin Damage and Skin Aging
    • Estrogen Deficiency Accelerates Spontaneous Skin Aging and Stimulates UV-Induced Photoaging of Murine Skin
  • Section 2: Current Treatment and Prevention Strategies
    • Sunscreens: Preventive Treatment of Photodamage and Premature Aging
    • Retinoids and Retinoic Acid Treatment of Aging
    • Chemical Peels, Dermabrasion, Botulinum Toxin, and Fillers in the Treatment of the Aging Face
    • Mechanisms of Skin Whitening Agents
    • Antioxidants for the Prevention of Photoaging
  • Section 3: Aged, Dry Skin
    • Characterization of and Strategies for Treating Dry Skin
    • Technical Bases of Biophysical Instruments Used in Aging Skin Testing
  • Section 4: Other Future Trends
    • Nutrition and Skin Aging
    • Strategies for Skin Aging, Focusing on Changes in DNA and Tissue Repair Systems
    • Vitamins and Aging Skin Treatment
    • Glycation and Oxidative Stress: Role in Skin Aging
    • Growth Factors and Aging Skin Treatments
    • Hormones, Metabolism and Skin Aging
  • Index

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